Programming and support:  SSMU IC

Teleconferences

Lecture Series on Regenerative Medicine

This is the programme of the distance learning lecture series on Regenerative Medicine designed for English speaking medical students of the Stavropol State Medical University.

The lecture series will be delivered by an international team of experts in stem cell biology and regenerative medicine.

Convened by:

Dr. D. Widera, Lecturer (Assistant Professor) in Stem Cell Biology and Regenerative Medicine, University of Reading, UK, Visiting Prof. StSMU

Email: d. widera[at]reading.ac.uk

Prof. Dr. Wolf-D. Grimm, Witten/Herdecke University, Germany, and Stavropol State Medical University, Stavropol, Russian Federation

Email: prof_wolf.grimm@yahoo.de

Introduction

prom1.jpgAccording the NIH report on Regenerative Medicine 2006, «the Greek titan, Prometheus, is a fitting symbol for the regenerative medicine». In Greek mythology, Zeus ordered Prometheus to be chained to a rock as a punishment for providing the mankind with fire. He also sent an eagle to eat Prometheus` liver day by day and enabled his liver to regenerate itself daily, enabling him to survive his eternal punishment.

Nowadays, scientists and physicians jointly hope to use the concept of regeneration to restore, repair, replace, and regenerate cells or tissues lost due to degenerative disorders or acute trauma (the 4 R`s of regenerative medicine).

Both, stem cell biology and regenerative medicine have become one of the most rapidly expanding fields in translational medicine. The lecture series on regenerative medicine as a distance learning programme designed for English speaking medical students at the Stavropol State Medical University will cover most current and emerging aspects of regenerative medicine and will cover (among others) modern stem cell technology, gene therapy (including most recent approaches like CRISPR/Cas9), biomaterials, and combined approaches to achieve the 4 R`s. The lectures will be held by an international expert team and provide a valuable opportunity for our international medical scholars to connect and engage with current and emerging field of medicine. In addition to general knowledge of the topic, the lecture series will provide the students with all tools and information to critically discuss current progress of the field and will also regulatory and ethical issues arising within the field.

International Expert Teaching Team

Dr. Darius Widera (Dr. rer. nat. habil., Dipl. Biochem.), Lecturer (Assistant Professor) in Stem Cell Biology and Regenerative Medicine, University of Reading, UK

Visiting Prof., StSMU), convenor of the lecture series.

Prof. Widera`s past and current research is focused on adult and embryonic stem cells and the molecular mechanisms that regulate their fundamental biological properties including differentiation, proliferation, and migration. His group is also interested in the impact of pro- and anti-inflammatory signals on neural stem cells (ancestors of nerve and glial cells), mesenchymal stem cells (progenitor of bone, fat and cartilage tissue) and neural crest-derived cells (progenitor of e. g. pigment cells and bones within the head region).

Prof. Dr. Wolf-Dieter Grimm, PhD, MSc, Professor of Periodontology, Witten/Herdecke University, Germany, Stavropol State Medical University, Stavropol, Russian Federation, convenor of the lecture series

Prof. Grimm`s research is focused on the use of stem cells in advanced regenerative periodontology and dental implantology. In a standardised animal model, he has investigated periodontal and alveolar bone regeneration. Nowadays, he and his research team are developing new techniques for alveolar bone regeneration using different carrier materials for neural crest-derived stem cells (NCSCs) in large animal models and in patients.

Prof. Dr. Frank Witte, Julius Wolff Institute and Center for Musculoskeletal Surgery, Berlin-Brandenburg Center for Regenerative Therapies, Charité - University Medicine Berlin, Germany

Prof. Witte`s research interests are the biology of bones, degradable biomaterials and biodegradable magnesium alloys, synchrotron-radiation based microtomography, immune response to biomaterials (in vitro and in vivo) along with in vivo fluorescence imaging for biomaterial-host interactions.

Prof. Dr. Thomas Dittmar, head of the working group `Stem Cells`, Institute of Immunology, Witten / Herdecke University, Germany

The research of Prof. Dittmar is focused on the role of stem cells in cancer progression. It is well recognized that bone marrow-derived stem cells (BMDCs), comprising of HSPC and mesenchymal stem cells (MSCs), are mobilised and recruited to degenerated tissues in response to inflammatory conditions, where they contribute to the regeneration of the degenerated tissues

Likewise, the tumor cell / stem cell hybrids possess an altered migratory phenotype, whereby the cells respond to factors which direct the organ-specific metastatic spreading of tumor cells.

Timetable

24/03/2016: Opening Lecture: Introduction in Regenerative Medicine

Prof. Dr. Widera, University of Reading, UK, and Prof. Dr. Wolf-D. Grimm, Witten/Herdecke University, Germany

IMG_7337.JPGIMG_7340.JPG

07/04/2016: Personalised Medicine and Gene Therapy

Prof. Dr. Widera, University of Reading, UK

19/05/2016: Stem Cells and Regenerative Medicine

Prof. Dr. Widera, University of Reading, UK

26/05/2016: Stem Cell Technologies in Regenerative Periodontology and Dental Implantology

Prof. Dr. Wolf-D. Grimm, Witten/Herdecke University, Germany

02.06.2016: In Vitro and in Vivo Evaluation of Scaffolds in Regenerative Medicine

Prof. Dr. Frank Witte, Julius Wolff Institute and Center for Musculoskeletal Surgery, Berlin-Brandenburg Centre for Regenerative Therapies, Charité - University Medicine Berlin, Germany

09.06.2016: Cancer Stem Cell Research

Prof. Dr. Dittmar, working group `Stem Cells`, Institute of Immunology, Witten/ Herdecke University, Germany

16.06.2016: Assessment and feedback

Prof. Dr. Widera, University of Reading, UK, and Prof. Dr. Wolf-D. Grimm, Witten/Herdecke University, Germany

Readinglist

Recommended reading

Textbook:

Alberts, B et al. (4th, 5th or 6th edition) Molecular Biology of the Cell 5th ed. Garland Science.

E-Book (open access):

http://www.stembook.org/

Review articles:

—  Special issue of Human Molecular Genetics journal of Stem Cells and Regeneration (all articles are open access), Volume 17 Issue R1 April 15, 2008

—  Regenerative medicine: Current therapies and future directions. Mao AS, Mooney DJ. Proc Natl Acad Sci U S A. 2015 Nov 24;112 (47):14452−9. doi: 10.1073/pnas.1508520112. (open access)

Assessment

The knowledge of all students attending the lecture series will be collected as formative assessment during the last session of the lecture series using an appropriate online tool (free of charge). Detailed instructions will be provided not later than one month prior to the assessment.

Lecture Slides / Handouts

All students attending the lecture series will be provided with lectures slides and/or handouts after as freely accessible pdf-file.