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STUDY OF HEPATOTOXICITY OF NIOSOMAL FORM OF DOXORUBICIN

Bazikov I. A., Beyer E. V., Maltsev A. N., Goptareva E. A., Malinina N. I., Botasheva V. S., Korolkova V. I. Stavropol State Medical University, Russia

The study of chronic toxicity of the niosomal form of doxorubicin when administered systemically to a maximum dose of 2.6 mg/kg has a moderate hepatotoxicity, which was manifested in the cytolytic syndrome and in violation of hematopoiesis and hemostasis parameters. Reducing the dose of niosomal form of doxorubicin to 1.6–2.0 mg/kg did not cause changes in hematological, biochemical and pathological parameters of laboratory animals.
Keywords: niosomes, doxorubicin, hepatotoxic effects, cytolytic syndrome
Interaction niosomal doxorubicin cell membranes.
Bazikov I. A., Lukinova V. V., Maltsev A. N., Diskaeva E. I., Aytekova S. R.
Study of change in the physical and structural properties of the membranes in contact with niosomal form of doxorubicin showed that the incorporation of niosomes increases membrane fluidity. As a result, they are becoming more permeable to water and other small hydrophilic molecules, increasing the speed of lateral diffusion of integral proteins. This increases the speed of transport, including the drugs through cell membranes, which in our opinion, is one of the mechanisms to increase the efficiency of therapeutic action of niosomal form of doxorubicin.
Key words: doxorubicin, niosomes, membranes.
STUDYING OF THE NANOVESICLES OF SILICONE NATURE, USED FOR TRANSDERMAL DELIVERIES OF ACTIVE SUBSTANCES
I.A. Bazikov, P.A. Omelyanchyk, E.M. Hatkov, A.L. Ghukassian, Z.A. Seiranidu
The purpose of research was studying the sizes and stability of nanovesicles of silicone nature. Measurements of nanovesicles carried spectrometer and raster electronic microscopy. Electrostatic stability defined by measurement of zeta-potential of samples emulsion with the help of system for the characteristic of nanovesicles. Results of researches of the sizes nanovesicles a method dynamic light to disseminate and the data received by raster electronic microscopy have shown the size from 20 up to 100 nanometres. The analysis of measurements of zetа-potential of nanovesicles, has shown about their electrostatic stability.